Find known EGFR inhibitors in ChEMBL, then score the 20,000 analogs in my library for drug-likeness and predicted binding to the EGFR kinase domain. Rank the top 50.
Find randomized trials of SGLT2 inhibitors in heart failure with preserved ejection fraction, extract hospitalization outcomes, and pool them in a meta-analysis.
Find lithium-containing oxides likely to be stable and to conduct lithium ions well. Rank the top 20 and show how confident each prediction is.
Sweep our driven oscillator model over a 40 by 25 grid of damping ratio (0.05 to 0.5) and drive amplitude, 1,000 runs in all. Chart amplitude against drive frequency and flag where the peak shifts.
Make a target dossier for LRRK2 in Parkinson's disease: genetic evidence, protein structure, known compounds, and every clinical trial so far.
Compare my draft phase 2 protocol for moderate psoriasis with similar trials on ClinicalTrials.gov: sample size, eligibility, sites, duration and whether they finished.
Here are 40 runs of our coupling reaction as a spreadsheet. Suggest the next 8 conditions most likely to raise yield, and explain why.
Fit this decay curve CSV with one and two exponentials. Compare the fits, report lifetimes with uncertainties and list outlier points.
Reproduce the dose response analysis in this bioRxiv preprint from its supplementary data and tell me if the reported IC50 values hold up.
Simulate 500 two-arm trial designs across effect sizes from 0.3 to 0.5, dropout from 5% to 20% and three allocation ratios, and tell me how many patients per arm each needs for 80% and 90% power.
These 12 XRD files are from our silicon anode batch. Compare each to the reference peaks and flag any sample with extra phases.
Reproduce figure 3 of the attached paper on spin chain dynamics and tell me which parameters the paper leaves out.
Compare the approved EGFR inhibitors for lung cancer: approval year, how they bind, and the resistance mutations each one covers.
Each month, check FDA's public adverse event files and PubMed for new reports of liver injury with my drug, and summarize what changed.
Compare published routes to carbon-coated lithium iron phosphate. Include precursors, temperatures, particle size and capacity, with the paper for each.
Here is my expression for the energy of a relativistic particle in a weak field. Check its low-speed and zero-field limits and its units.
Every Monday, check for new or updated trials of GLP-1 drugs in obesity and flag any status change, new results or company filing.
Here is our de-identified trial export as a CSV. Compare time to relapse between arms and draft the results section.
We use DMF and NMP in our polymer process. List replacement solvents with similar properties and the papers that tested them.
Every Monday, find new preprints on measurements of the muon magnetic moment and note whether they agree with our current analysis.
Pull this week's plate reader results for the kinase panel from Benchling and fit dose response curves for every compound.
Fit a model of how this drug moves through the body using the phase 1 data, then compare once-daily and twice-daily dosing.
Relax these 10 doped structures with a machine-learned potential, then run short molecular dynamics at 600 K and compare lithium diffusion.
Train a surrogate on our 500 plasma simulation outputs, then use it to infer the input parameters that best match this measured spectrum.
